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产品名称:
Amyloid Beta Protein
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别名:
Abeta Oligomers, Abeta peptide, Amyloid beta peptide oligomers, Beta amyloid peptide oligomers, amyloid beta precursor protein peptide oligomers, APP
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产品描述:
Human Synthetic Amyloid Beta 1-42 Oligomers
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反应种属:
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宿主来源:
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实验应用:
WB | In vivo Assay | In vitro Assay
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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免疫原种属:
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克隆性:
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克隆号:
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纯化方式:
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偶联:
No Tag
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-80ºC
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运输温度:
Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
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细胞定位:
Cell Membrane | Intracellular Vesicles
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预期分子量:
4.5 kDa
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产品形式:
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存储溶液:
Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
Our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (1,2). Our Aβ42 oligomers present as globular oligomers when observed under TEM and AFM, and have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody. Our Aβ42 oligomers were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner.
In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). Aβ oligomers generated in vitro were toxic to PC12 cells (5) and SH-SY5Y cells (6). Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (7) and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson’s disease patients with dementia (8).
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样本类型:
Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
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产品特点:
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纯度:
>95%
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生物活性:
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内毒素水平:
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