灵敏、快速的内皮素-1 ELISA试剂盒，适用于心血管和应激相关研究
内皮素（Endothelin, ET）是由血管内皮细胞产生的异肽，具有强大的血管收缩活性。这种肽由三个独立的基因编码，经过加工产生39个残基的 '大ET '分子，再进一步加工成21个氨基酸序列，命名为ET-1、ET-2和ET-3。ET的作用是通过与两个受体（ETA和ETB）的结合来介导的。ETA的激活会增加血管收缩和钠潴留，从而增加血压。ETB受体的激活引发血管舒张因子的释放，如内皮细胞的一氧化氮（NO）和前列腺素，并增加尿液的产生和排出，从而降低血压。
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产品特点
◆ 高灵敏度，可检测低至0.41pg/ml的ET-1，正常和病理样本均可检测
◆ 高通量，仅需2小时就能得到38份样本（含复孔）的检测结果
◆ 可灵活选择过夜或1小时孵育
◆ 适用于多种样本类型
产品信息
产品货号 | ADI-900-020A |
产品名称 | Endothelin-1 ELISA kit（内皮素-1 ELISA试剂盒） |
规格 | 96 wells |
灵敏度 | 0.41 pg/ml |
检测范围 | 0.78 - 100 pg/ml |
应用 | ELISA, Colorimetric detection |
适用样本类型 | For the quantitative determination of ET-1 in culture supernatants, plasma, and serum of human, mouse, rat, cow, dog, pig, and rabbit origin. Cited sample types include cell lysates and tissue homogenates. |
检测波长 | 450 nm |
适用种属 | Human, Mouse, Rat Bovine, Dog, Porcine, Rabbit |
运输 | Blue Ice Not Frozen |
长期保存 | +4°C |
试剂盒组分 | Microtiter plate, Antibody diluent, Antibody concentrate, Assay buffer 17, Wash buffer concentrate, Standard, TMB Substrate, Stop solution 2 |
标准曲线示例
部分产品引用文献
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2. Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia: M.J. Cipolla, et al.; J. Cereb. Blood Flow Metab. (2022)
3. Vasorin plays a critical role in vascular smooth muscle cells and arterial function: L. Louvet, et al.; J. Cell. Physiol. 237, 3845 (2022)
4. Contributions of Sodium-Hydrogen Exchanger-1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes: Y.L. Chen, et al.; Diabetes 70, 2353 (2021)
5. Dehulled Adlay Consumption Modulates Blood Pressure in Spontaneously Hypertensive Rats and Overweight and Obese Young Adults: W.-J. Jeh, et al.; Nutrients 13, 2305 (2021)
6. Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial: T.V. Dam, et al.; Menopause 28, 1214 (2021)
7. Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities: J. van de Wouw, et al.; Basic Res. Cardiol. 116, 51 (2021)
8. Anthocyanin-Rich New Zealand Blackcurrant Extract Supports the Maintenance of Forearm Blood-Flow During Prolonged Sedentary Sitting: M.J. Barnes, et al.; Front. Nutr. 7, 74 (2020)
9. Aerobic exercise training improves insulin-induced vasorelaxation in a vessel-specific manner in rats with insulin-treated experimental diabetes: M.W. McDonald, et al.; Diab. Vasc. Dis. Res. 16, 77 (2019)
10. Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial: B. Chew, et al.; Eur. J. Nutr. 58, 1223 (2019)
11. Gelatin-based perfusable, endothelial carotid artery model for the study of atherosclerosis: R. Chen, et al.; Biomed. Eng. Online 18, 87 (2019)
12. Hyperglycemia enhances constriction of retinal venules via activation of the reverse-mode sodium-calcium exchanger: Y.L. Chen, et al.; Diabetes 68, 1624 (2019)
13. In Vivo Comparative Study on Acute and Sub-acute Biological Effects Induced by Ultrafine Particles of Different Anthropogenic Sources in BALB/c Mice: F. Farina, et al.; Int. J. Mol. Sci. 20, 2805 (2019)
14. Co-ingestion of whole eggs or egg whites with glucose protects against postprandial hyperglycaemia-induced oxidative stress and dysregulated arginine metabolism in association with improved vascular endothelial function in prediabetic men: J.D. McDonald, et al.; Br. J. Nutr. 120, 901 (2018)
15. Effects of Personal Short-Term Exposure to Ambient Ozone on Blood Pressure and Vascular Endothelial Function: A Mechanistic Study Based on DNA Methylation and Metabolomics: Y. Xia, et al.; Environ. Sci. Technol. 52, 12774 (2018)
16. Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells: H.C. Lin, et al.; Environ. Toxicol. 32, 918 (2017)
17. Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats: A.M. Gad, et al.; J. Biochem. Mol. Toxicol. 31, (2017)
18. Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt: A. Wannhoff, et al.; Aliment. Pharmacol. Ther. 43, 955 (2016)
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